When bone marrow and other organs are transplanted, the higher the compatibility between donor and recipient human leukocyte antigen (HLA), the lower the incidence of rejection, the higher the success rate of transplantation and the long-term survival rate of transplanted organs. Conversely, the more likely rejection occurs. Beginning in July, Shenzhen Huada Gene applies next-generation sequencing technology, which can read the HLA sequence data of thousands of samples in one experiment and achieve the highest resolution of HLA typing at one time, while discovering new Alleles. There are qualitative leaps in terms of testing throughput, data quality, and cost control. Using this new technology for high-resolution matching, the cost is less than half of the traditional technology. It can avoid the extra economic burden caused to patients by multiple matching, and also win valuable time for treatment.
At present, most of the HLA typing data in the bone marrow bank in China is low-resolution, and it cannot ensure that the HLA of the donor and the patient are truly matched. The patient often needs to perform high-resolution review with multiple low-resolution matching volunteers to find a truly suitable donor . The high-resolution matching is expensive, and the cost of a high-resolution matching can reach 10,000 yuan. The latest HLA typing technology of BGI has made it possible to establish a high-resolution HLA database. The high-resolution database not only helps to find suitable donors quickly and accurately, greatly improve the utilization rate of bone marrow bank, but also can provide basic data support for scientific research and technological innovation of HLA.
Wang Jian, Dean of the BGI Research Institute, said that BGI has invested hundreds of millions of funds to specifically support the domestic bone marrow bank to convert existing low-resolution typing data into high-resolution typing data to improve the success of matching and transplantation. Rate, so that patients really benefit. At the same time, BGI is jointly developing new technologies for leukemia gene diagnosis with relevant experts in the field of hematology in China, and conducting a large-scale leukemia epidemiological survey in China to provide first-hand scientific information for the clinical diagnosis and treatment of leukemia.
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