Recently, the laboratory of Professor Deng Linhong of the School of Bioengineering of Chongqing University and the cooperative laboratory of Harvard University in the United States published a paper in the internationally renowned open-read comprehensive academic journal Plos One, revealing the internal mechanism of mechanical fluidization-induced cell fluidization response.
This collaborative research is the further deepening of Professor Deng Linhong and Harvard University collaborators after publishing a paper on Nature's Mechanical Response to Stretching in the Living Cell in Nature in 2007 (Nature 447: 592-595, 31 May, 2007). The paper published in Nature in 2007 first proposed that living cells will quickly soften and transform into a fluid state after receiving short mechanical stretch, and then gradually return to the state before stretching This phenomenon is universal in various cells and biochemical environments, so it is very important for understanding the physical behavior of cells and related physiological and pathological phenomena. However, the internal mechanism of this important phenomenon has not yet been fully revealed.
This paper published by Plos One not only uses another bladder smooth muscle cell in the body that is also affected by mechanical tension, which further confirms the universality of rapid fluidization and slow recovery of cells after short stretches, and Find out for the first time the key role F-actin has been observed in, at least in part, if not completely, reveal the inherent physical regulation mechanism of this phenomenon. With the common development of modern cell biology and cell dynamics, the mystery of how mechanical force and physical environment affect cell structure and function and determine many major life activities is being gradually opened. Therefore, while conducting traditional biological and chemical analysis on cells, systematically studying the physical environment and stress of cells and the corresponding cell behavior laws will provide a more accurate and in-depth understanding of the cell ’s operating mechanism and provide The research of physiology and pathology provides new inspiration and ideas.
In October 2008, Chen Cheng, a Ph.D. student of Professor Deng Linhong, as a PhD student jointly trained by Chongqing University and Harvard University in the United States, was sent to Harvard University to continue the flow of cells after mechanical stretching in the laboratory of Professor Fredberg, the American co-supervisor Research on internalization and its internal mechanism. After nearly two years of efforts, Chen Cheng, under the joint guidance of mentors from both China and the United States and the full cooperation with other collaborators, used cell tension micro-measurement technology, magnetic particles to reverse cell rheology measurement technology and other advanced technological dynamics in the field of cell mechanics Observed human bladder smooth muscle cells after a short mechanical stretch, its cell hardness, cell tension, and cytoskeletal morphology changes. The experimental results show that bladder smooth muscle cells quickly "liquefy" after being briefly stretched, then slowly "resolidify", and gradually return to the state before stretching. More importantly, because the duration of the short stretch is very short, all physical corresponding processes in the cell are not regulated by biochemical signaling pathways inside the cell, but by fibrous actin (F- actin) is quickly decomposed and slowly reorganized to achieve and regulate.
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