Vacuum freeze-drying technology has a wide range of applications in the fields of bioengineering, pharmaceutical industry, food industry, materials science and deep processing of agricultural and sideline products. Freeze-drying of drugs includes two parts: western medicine and traditional Chinese medicine. Western medicine freeze-drying has been developed in China, and many larger pharmaceutical plants have freeze-drying equipment. In terms of injection, the freeze-drying process is used more, which improves the quality and shelf life of the drug, and brings benefits to both doctors and patients. There are not many varieties of freeze-dried medicines, the prices of products are high, and the drying process is not advanced. In traditional Chinese medicine, it is limited to the lyophilization of a small amount of Chinese medicinal materials such as ginseng, velvet, yam, and Cordyceps sinensis. A large number of proprietary Chinese medicines have not been freeze-dried, which is far from the foreign countries.
A few years ago, Japan launched the "Western Chinese Medicine" system, which changed the method of tanning of traditional Chinese medicine, solved the tradition that Chinese medicine could not be made into injection or tablet, and solved the problem of Chinese medicine not treating acute illness. Therefore, the Chinese traditional medicine freeze-drying process And product research has great potential to dig. In the field of biotechnology products, freeze-drying technology is mainly used for the production of drugs such as serum, plasma, vaccines, enzymes, antibiotics, hormones; biochemical inspection drugs, immunology and bacteriology; drugs; blood, bacteria, arteries, bones Long-term preservation of skin, cornea, nerve tissue and various organs. The current status of equipment and the development of freeze-drying technology applications and equipment are inseparable. So far, the form of freeze-drying equipment is mainly divided into two types: intermittent and continuous. The scale of equipment ranges from less than one square meter to several Ten square meters are available. Intermittent freeze-drying equipment Intermittent freeze-drying equipment is suitable for multi-species small-scale production, especially in the food field for seasonal strong food production. With stand-alone operation, if one device fails, it will not affect the normal operation of other devices. Intermittent freeze-drying equipment is convenient for controlling the heating temperature and vacuum requirements of different stages of material drying. The manufacturing, maintenance and repair of the equipment is easy. However, since the operations such as loading, unloading, and starting take more time, the equipment utilization rate is low and the production efficiency is not high.
Continuous freeze-drying equipment began to explore and use continuous vacuum freeze-drying equipment at home and abroad. The continuous equipment is characterized by the production of a single product with a large output and sufficient raw materials, especially for the production of pulp and granular products. Continuous equipment is easy to implement automatic control, simplifying manual operation and management, and its main disadvantage is high cost. With the end of GMP certification, the domestically produced excellent freeze-drying equipment for medical use has entered the modernization stage. It has complete functions, reliable work and stable performance. It can be used for online cleaning or steam sterilization. All technical indicators can meet biological products and The need for lyophilization of pharmaceutical products.
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